Hyaline cartilage material synthesis can be advertised by growth variables, such as transforming growth factor-ß (TGF-ß) or bone morphogenic proteins (BMP) [3] Cartilage is not innervated and is avascular; because of this, chondrocytes subsist in hypoxia [4] Oxygen is supplied to the cartilage through the synovial liquid, halal collagen in part secreted by synoviocytes, or with diffusion from the subchondral bones; oxygen focus vary from 1 to 10% depending upon the depth of the tissue [5] Essen...