Glucophage CAN contribute to minor weight letters. Mind that Glucophage is just a part of complete therapy that also includes exercising, healthy diet, weight management and proper medical care. Doing so may occasionally trigger a reaction in some patients similar to the disulfiram reaction, which includes unpleasant effects such as flushing, throbbing in head and neck, throbbing headache, difficulty breathing, nausea, vomiting, sweating, thirst, chest pain, rapid heartbeat, palpitation, low bl...